By the close of the Industrial Revolution, the food supply in the United States was tainted with frauds, fakes, and legions of new and untested chemicals, dangerously threatening the health of the public. The Poison Squad, based on the book by the same name from author Deborah Blum, tells the story of Dr. Harvey Wiley, a government chemist who was determined to banish these dangerous substances from dinner tables, and so took on powerful food manufacturers and their allies. Wiley embarked upon a series of bold and controversial trials on 12 human subjects who would become known as the “Poison Squad.” Following Wiley’s unusual experiments and tireless advocacy, the film charts the path of the forgotten heroes who together laid the groundwork for consumer protection laws in the United States, and ultimately, paved the way for the creation of the Food and Drug Administration.